Categories
Functional Medicine Health Concerns

How to Heal Your Thyroid

 

What Does the Thyroid Do?

The thyroid produces two thyroid hormones (T4 and T3) and calcitonin (which helps to lower calcium and phosphate levels in the blood by helping the bones absorb more calcium).  The thyroid hormones are essential for metabolism, as well as normal growth and development. They influence every cell in your body. They maintain the rate at which your body uses fats and carbohydrates, help control your body temperature, influence your heart rate, and help regulate the production of protein.

Unfortunately, most doctors focus on the individual hormones instead of the nutrients and processes that make those hormones. Thyroid dysfunction is a symptom of a much larger, whole body issue. It is just one piece of the puzzle.  Medicating the thyroid is a bandaid, and is not actually addressing any of the underlying issues going on.

The regulation of the thyroid hormones depends on the relationship between the anterior pituitary and the thyroid gland.  The pituitary secretes the thyroid stimulating hormones. This is why the HPA axis is so important in our health and why we can’t just focus on one part of the body. The HPA axis is the hypothalamus/pituitary/adrenal axis. If the HPA Axis is under stress, then the HPT axis is under stress as well- they are connected, and the HPA axis tends to take precedence. You cannot heal the thyroid if your adrenals aren’t healthy.

Gut Healing and Thyroid Health

The gut is one of the first steps to address in healing from any illness. The gut encompasses so much – digestion and nutrient assimilation, gut microbiome, gut/brain axis, and lots of inflammation can stem from the gut!

Stomach acid is so important for utilization of the nutrients needed to support a healthy thyroid, especially copper, iron, potassium and more. When our gut is out of balance, it can increase inflammation in the body which will stress out our HPA axis (and HPT axis). The conversion of thyroid hormones also depends on a healthy microbiome.[/vc_column_text]

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Liver Healing and Thyroid Health

The liver has hundreds of functions in the body. If it is not happy, then lots of things can being going wrong in the body and many processes start failing. Regarding the two thyroid hormones – T4 and T3, T3 is the ONLY form of thyroid hormone that the cells can use. T4 must be converted to T3 before it can be used by the cells. Guess where that conversion takes place?  Yep, in the liver! Thanks to the state of our food and environment, so many people have sluggish lovers because it gets sluggish when we have nutrient deficiencies, chronic underlying infections, and if we have lots of toxins.

Some of our favorite liver healers are castor oils packs, herbal infusions, bitter herbs like dandelion root, bioray liver life and liver detoxes.

There’s also high amounts of autoimmune thyroid issues these days (caused mostly by underlying infections like Lyme and EBV), but also from inflammation from many causes, including gluten and caffeine.

Avoiding gluten, processed foods, and goitrogenic foods like soy, can also help the thyroid. Focusing on a whole foods, organic diet with healthy fats and proteins is essential.

There’s a lot of focus on iodine for thyroid health but in isolated form, it can cause problems for some people. So, unless recommended by your practitioner, it’s best to get it from a good, clean source of sea veggies. Maine Coast Sea Veggies is a great brand!

Selenium is also a very important factor in thyroid health. A Brazil nut a few times a week will cover your selenium needs!

Recap:

There is a lot to thyroid health!

Balancing minerals, replenishing other nutrients, healing the gut, and healing your liver are imperative for healing the thyroid.

Addressing any underlying infections or toxicities will help as well.

Since there are many variations in thyroid dysfunction, fixing the thyroid will be different for most people.

Here are some things you can do now to help your thyroid:

  • Cervical spine chiropractic care
  • Addressing trauma’s and feeling “heard”
  • Addressing oral health such as amalgams & root canals as these are a direct download to the thyroid.
  • Nourish your body with minerals through whole food, natural sources.
  • Avoid taxing toxins & toxicants such as BPA, bromine, mercury, and lead. As these all compete with the receptors for iodine thus inhibiting thyroid hormone production!
    • Cans
    • Strawberries (conventional)
    • Tuna
    • Lead
    • Pesticides
    • Herbicides

Need More Help?

Specific Testing & Working with a Provider

More sources for thyroid healing:

Dr. Brad Shook has many great videos about thyroid health, like this one!

Liver thyroid connection

Gut thyroid connection

Gut thyroid connection: Dysbiosis and Thyroid Dysfunction

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Categories
Functional Medicine Health Concerns

A Functional Approach to PCOS

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Polycystic Ovarian Syndrome

Known as PCOS, this condition can happen at any age after puberty. Every month, as part of a healthy menstrual cycle, the ovaries release an egg. In women that have PCOS, the ovaries will develop a thickened outer wall underneath which many partially stimulated eggs form cysts, hence the name polycystic ovarian syndrome.

Normally, the ovaries release a small amount of male sex hormones, called androgens. However, in women with PCOS, the ovaries start making slightly more androgens – which is the reason for masculine symptoms like extra facial and body hair and male pattern baldness.

Traditionally, the diagnosis of Polycystic Ovarian Syndrome was made when an imaging study revealed multiple cysts on the ovaries. We now know not every woman diagnosed with polycystic ovarian syndrome has visible cysts on her ovaries. Polycystic ovarian syndrome can still be diagnosed if the majority of other common symptoms are experienced and/or they have the common endocrine abnormalities associated with PCOS. This is because the “cysts” are actually just increased number of follicles.

How Do I Know If I Have PCOS?

Pay attention to your body! Your body is wonderfully and brilliantly made. It will tell you if something is off. At the start of your next cycle, pay attention to these signs.

Symptoms of PCOS:

  • Trouble getting pregnant (infertility)
  • Irregular menstrual cycle
  • Hirsuitism, with hair growth on the face, chin, or parts of the body where men usually have hair
  • Acne on the face, chest, and upper back
  • Thinning hair or hair loss on the scalp; male-pattern baldness
  • Weight gain or difficulty losing weight
  • Darkening of skin, particularly along neck creases, in the groin, and underneath breasts, which is commonly associated with insulin resistance
  • Anxiety and depression
  • Elevated waist to hip ratios, overweight and obesity
  • Fatigue

What Causes PCOS?

While the exact cause of PCOS is unknown, several factors, including genetics, diet, stress levels, and environmental toxins can all play a role because they influence your hormones. The common hormonal imbalances associated with PCOS include high androgens (testosterone/DHEA), overproduction of CRH (corticotropin releasing hormone) and cortisol, elevated insulin/glucose levels, elevated estrone levels and improper ratios of LH (lutenizing hormone) to FSH (follicle stimulating hormone).

High insulin is not just a symptom, it is a major driver.

The body makes insulin but can’t use it correctly increasing risk for T2DM. Insulin lowers your blood sugar by storing glucose in cells. The cells become resistant to the constant insulin and need more to be signaled to lower the blood sugar. When the resistance goes on for a while, this results in high insulin and high blood sugar.

Can I Treat PCOS Naturally?

Diet and exercise are the most fundamental ways to manage insulin and PCOS! Our Functional Medicine providers recommend engaging in moderate exercise for at least 30 min per day to regulate blood sugar.
Regular movement throughout the day helps your body use sugar as it was designed to and, therefore, improve insulin sensitivity!

Things you can do to improve hormone balance and reduce PCOS:

  • Avoid high sugar foods and having low carb diet, rich in protein and fat balance blood sugar.
  • Avoid excess caffeine
  • Prioritize sleep and reduce stress
  • Avoid xenoestrogens/endocrine disruptors – non organic meats/dairy, skincare/cleaning products
  • Replace tampons with pads or menstrual cups
  • Supplements: high quality, recommended magnesium, NAC, inositol, berberine
  • Red light laser therapy (photobiomodulation)

 

Here’s What You Can Do Today

Better Food and Finding a Healthy Weight if Overweight

Consuming a nutrient-dense, low-glycemic diet will improve insulin sensitivity, body composition and androgen levels. In the Journal of Obesity, participants followed a low starch/low dairy food plan for 8 weeks, which resulted in a decrease in testosterone, improved insulin sensitivity and weight loss. In addition, there may be some association with improper detoxification and bodily retention of environmental toxins in patients with PCOS. We suggest most patients consume a whole foods diet, limiting exposure to pesticides, preservatives, and artificial sweeteners. Include a plethora of non-starchy vegetables, grass-fed/pasture-raised meat/poultry, wild-caught fish (salmon is my favorite), nuts/seeds and unrefined oils/fats like coconut oil, olive oil and avocado.

Stress Management

Increased stress will elevate your cortisol levels which in turn elevates blood glucose levels. This will lead to increased weight gain around the abdomen as well as an increase in androgen levels. Excess androgen levels can lead to aromatization and an increase in estrone levels created by the increase in adipose (fat) tissue. Elevated estrone levels disrupt the proper ratios of LH and FSH that lead to menstrual irregularities and the many other symptoms associated with PCOS. Many patients admit to experiencing stress in their lives, however, most are not aware of the real physiological changes that occur when they feel stressed.

Some suggestions for reducing stress are to spend more time in nature, try mindful movement, breathing, and meditation a few times per week. Start a heart-centered meditation, engage in daily prayer, start a journal and ensure that you are getting proper sleep (at least 7-9 hours per night). Other suggestions include acupuncture, energy therapy such as marma therapy, massage and/or chiropractic.

Exercise

Getting regular movement is part of any treatment plan for patients diagnosed with PCOS. It is important to engage in moderate activity to improve body composition, burn fat and lower cortisol levels. Some women make the mistake of engaging in extremely intense activity, which can actually cause more hormonal imbalances. As a general rule, we recommend listening to your body and paying attention to how you feel during and after your exercise routine.

Herbal Medicine

Herbs known as adaptogens can help promote hormone balance and protect the body from the effects of cortisol caused by chronic stress. Ashwaganda, holy basil, rhodiola and maca root can are a few of the herbs that can be helpful in PCOS. Licorice can lower testosterone levels, however, care must be taken if you also have hypertension.  Inositol is another commonly used supplement to improve symptoms associated with PCOS, although it seems to be more helpful in the patients that are not classified as obese. There are two types of inositol: myo-inositol and D-chiro-inositol and doses somewhere between 1,200-2,400 milligrams per day can help with follicular maturation, weight loss, reducing leptin levels , lowering triglyceride levels and improving HDL levels. Lastly, omega- 3 supplementation can affect gene expression that is involved in insulin and lipid signaling pathways.

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We’re Here to Help You

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References & Further Reading

  1. Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol. 2013;6(1):1-13. doi:10.2147/CLEP.S37559
  2. Sirmans SM, Parish RC, Blake S, Wang X. Epidemiology and comorbidities of polycystic ovary syndrome in an indigent population. J Investig Med. 2014;62(6):868-874. doi:10.1097/01.JIM.0000446834.90599.5d
  3. Ding T, Hardiman PJ, Petersen I, Wang FF, Qu F, Baio G. The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta-analysis. Oncotarget. 2017;8(56):96351-96358. doi:10.18632/oncotarget.19180
  4. Gibson-Helm M, Teede H, Dunaif A, Dokras A. Delayed diagnosis and a lack of information associated with dissatisfaction in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2017;102(2):604-612. doi:10.1210/jc.2016-2963
  5. Mathur R, Ko A, Hwang LJ, Low K, Azziz R, Pimentel M. Polycystic ovary syndrome is associated with an increased prevalence of irritable bowel syndrome. Dig Dis Sci. 2010;55(4):1085-1089. doi:10.1007/s10620-009-0890-5
  6. Cooney LG, Lee I, Sammel MD, Dokras A. High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2017;32(5):1075-1091. doi:10.1093/humrep/dex044
  7. Jason J. Polycystic ovary syndrome in the United States: clinical visit rates, characteristics, and associated health care costs. Arch Intern Med. 2011;171(13):1209-1211. doi:10.1001/archinternmed.2011.288
  8. Schmidt TH, Khanijow K, Cedars MI, et al. Cutaneous findings and systemic associations in women with polycystic ovary syndrome. JAMA Dermatol. 2016;152(4):391-398. doi:10.1001/jamadermatol.2015.4498
  9. Lim SS, Hutchison SK, Van Ryswyk E, Norman RJ, Teede HJ, Moran LJ. Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2019;3:CD007506. doi:10.1002/14651858.CD007506.pub4
  10. Lua ACY, How CH, King TFJ. Managing polycystic ovary syndrome in primary care. Singapore Med J. 2018;59(11):567-571. doi:10.11622/smedj.2018135
  11. Kazemi M, McBreairty LE, Chizen DR, Pierson RA, Chilibeck PD, Zello GA. A comparison of a pulse-based diet and the therapeutic lifestyle changes diet in combination with exercise and health counselling on the cardio-metabolic risk profile in women with polycystic ovary syndrome: a randomized controlled trial. Nutrients. 2018;10(10):E1387. doi:10.3390/nu10101387
  12. Wolf WM, Wattick RA, Kinkade ON, Olfert MD. The current description and future need for multidisciplinary PCOS clinics. J Clin Med. 2018;7(11):E395. doi:10.3390/jcm7110395

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Categories
Functional Medicine Health Concerns

Men’s Health

According to the CDC, women are 100% more likely to visit the doctor for annual examinations and preventive services than men. Here at Kingdom Health, half of our patients are men (usually thanks to some caring yet persistent women)! Nonetheless, kudos to you awesome guys!!
Thank you for understanding that your body was created intelligently. And, that admitting when there is an interference, taking the steps to seek care, and then taking action allows you to live fuller so you can get back to doing the things you love.

There is a silent health crisis in America…it’s that fact that, on average, American men live sicker and die younger than American women.” Dr. David Gremillion Men’s Health Network

The main reasons men come to our office is due to symptoms of hormonal imbalance such as:

  • hair loss
  • muscle mass loss
  • loss of bone mass, otherwise known as osteoporosis
  • difficulty concentrating
  • hot flashes
  • erectile dysfunction
  • cognitive decline
  • depression
  • fatigue
  • memory loss

We also see men due to hypertension, cardiovascular health, inflammation, gut issues, and food sensitivities – because, like so many, prescription medication wasn’t fixing anything.

Men tend to wait until its the last resort until seeking help – DON’T WAIT! There are better options out there!

Here at Kingdom Health, we do not guess – we test. Our providers start care with in-depth functional testing – not your conventional lab work.  We test based on your individual health history, your symptoms, and your lifestyle. And, the test we do are full panel tests so that we can uncover what is going on physiologically and biochemically.

Comprehensive testing provides our patients with information and knowledge about the function of their body that they typically do not receive from their conventional doctor visits. These tests are performed to get to the root cause of the symptoms or disease.
In addition to helping resolve health issues, we also have testing to optimize health. Perhaps you are feeling good but you want to feel and function even better. We have testing that analyzes the factors of aging and then allows us to modify these factors. The goal is to Function Optimally and to Thrive, not to merely ‘not be sick’.

HORMONE OPTIMIZATION plays a huge role in not only women’s health but men’s health as well! Testing helps us uncover root of these symptoms so we can work with you to create a plan that will get your body back to optimal health!

Better energy, better libido, better recovery, better gut health, better moods! These are all things are male patients walk out of our office saying.

Don’t wait until it’s too late to start LIVING life!

Resources & Further Reading:
https://www.menshealthnetwork.org/healthfacts
J Chiropr Med. 2008 Sep;7(3):86-93.
J Manipulative Physiol Ther. 2012 Jan;35(1):7-17
Categories
Functional Medicine Health Concerns

A Functional Approach to a Healthy Weight

I started my program focused on gut health & overall better function in the body – and the weight just took care of itself!!

Approaching Weight from a Functional Perspective

Healthy Weight: (adj. + n.) a body’s relative mass or the quantity of matter contained by it, that does not negatively impact but rather regulates optimal bodily functions; can be comfortably maintained with lifestyle and does not consume one’s thoughts.

You take up space. A measurement of space is weight. The weight of your body is a compilation of purpose! Down to every one of your 724+/- trillion cells.

One of the beautiful things about how we are designed is that we have the ability to guide the purpose of our cells by what we do and how we live.

An Integrative Approach to Healthy Weight

The etiology of unhealthy weight in today’s world is multi-factorial including genetic, psychosocial, emotional, behavioral and environmental factors.  Achieving and maintaining a healthy weight may require attention to deeper issues in all aspects of lifestyle including:

  • Nutrition
  • Mindfulness
  • Physical activity
  • Lifestyle imbalances
  • Stress management
  • Quality sleep
  • Spiritual connection

Addressing Root Issues

When journeying on the path to a healthy weight, it is necessary to address not the symptom of unhealthy weight but rather the root issues that is causing it. With functional medicine, providers often do in-depth testing to uncover what is going on or not going on internally such irregular thyroid activity, insulin resistance, hormonal imbalances, toxic overload, nutrient deficiencies or imbalances, etc.

Evidence suggests the following therapies may be helpful for weight management:

  • Body therapies such as chiropractic, message therapy, and acupuncture
  • Mind-body techniques such as meditation, breathing exercises, and artistic expression
  • Talk therapy including counseling, support groups and motivational interviewing

“We used to eat to fill our stomachs but now we eat to fill our hearts.” – Dr. Rangan Chatterjee

If we stop to look at the real reasons people eat certain foods, it’s not a lack of self-control like the stigma suggests- it is a lack of other things in life.

Don’t Weight! A Better Approach to Healthy Weight

Here are five key elements that can help us tune into our hunger cues, emotional needs, and physical responses to food in a way that makes us feel better overall, with weight loss as an added benefit. Stopping to ask yourself what, when, why, where, and how, every time you eat, creates a sense of awareness and sustainable results that are often missing from diet culture.

When we regulate the body’s biological systems, we automatically regulate the brain chemistry, hormones, and other factors that can lead to an unhealthy weight when left unchecked. And, when we begin to understand that the food industry knows how to hijack those systems at the highest level, we can stop blaming ourselves and start making positive changes!

If the body still can’t seem to find its healthy weight, seek assistance! There may be deeper issues going on.

Schedule An Appointment

Categories
Functional Medicine Health Concerns

A Functional Approach to Inflammation

What is Inflammation?

Inflammation – we know you’ve heard of it.
You probably know it is a root cause of countless health problems and is the only factor common to all chronic diseases – including Alzheimer’s & dementia due to an antimicrobial response to pathogens or other inflammatory causes. The word inflammation comes from the Latin word inflammatio; inflammare which means to set on fire. The best way to describe inflammation is to say the tissues of the body are “on fire.” Your body is creating this fire in response to damaged cells in your body.

What Causes Inflammation?

In functional medicine, we are very interested in the subject of #inflammation because until it is brought under control we simply cannot help people’s bodies restore function and therefore health. When your cells are damaged by anything, your body starts a fire. The purpose of this fire is to contain/limit the damage so it does not spread, break down damaged cells for removal and permit the development of new, healthy cells — just like controlled burns in nature!
So, while your body is not technically on fire, inflammation is like a fire in your body. But, what causes this body-fire? A lot of natural chemicals your body creates in a response to damaged cells.

Below are some of the chemicals your body makes to create this fire:

“Body-Fire Chemicals”

  • Histamine
  • Bradykinin
  • Serotonin
  • Prostaglandins
  • Complement system (a group of about 20 different proteins)
  • Cytokines including lymphokines and monokines
  • Etc.

As you can see from the list above, the process of inflammation is not caused by a single chemical; it is a complicated process, involving many different chemicals. This is why so few people understand what inflammation actually is… there is not a single cause. You just need to know that inflammation is like a fire in your body.

What Triggers an Inflammatory Response?

Inflammation is an immune response. Innate immune response is how your body recognizes and defends itself against bacteria, viruses, and substances that appear foreign and harmful. The inflammatory response (inflammation) occurs when tissues are injured by bacteria, trauma, toxins, heat, or any other cause that damages cells including microorganisms, physical agents, chemicals, inappropriate immunological responses, and tissue death.

Infectious agents such as viruses and bacteria are some of the most common stimuli of inflammation. Viruses give rise to inflammation by entering and destroying cells of the body; bacteria release substances called endotoxins that can initiate inflammation.

Physical trauma, burns, radiation injury, and frostbite can damage tissues and also bring about inflammation, as can corrosive chemicals such as acids, alkalis, and oxidizing agents. As mentioned above, malfunctioning immunological responses can incite an inappropriate and damaging inflammatory response. Inflammation can also result when tissues die from a lack of oxygen or nutrients, a situation that often is caused by loss of blood flow to the area.

The damaged cells release chemicals including histamine, bradykinin, and prostaglandins. These chemicals cause blood vessels to leak fluid into the tissues, causing swelling. This helps isolate the foreign substance from further contact with body tissues.

The chemicals also attract white blood cells called phagocytes that “eat” germs and dead or damaged cells. This process is called phagocytosis. Phagocytes eventually die. Pus is formed from a collection of dead tissue, dead bacteria, and live and dead phagocytes.

Most Common Causes of Inflammation That We See

  1. Chronic Infections – such as infections of the gut, Lyme’s Disease, Epstein–Barr virus, etc
  2. Food Sensitivities
  3. Genetic Issues – MTHFR, Catechol-O-methyltransferase (COMT)
  4. Heavy Metals

Healthy vs Chronic

When inflammation is short-term and controlled, it is a very good thing because it is a necessary part of the healing process. The “fire” of inflammation cleans out the useless and damaged cells and lets new healthy ones take their place. This is what we call “healthy inflammation.”  Every time we eat, we also consume a significant quantity of bacteria. The body is faced with the challenge of simultaneously distributing the ingested glucose and fighting these bacteria. This triggers an inflammatory response that activates the immune systems of healthy individuals and has a protective effect In healthy individuals, short-term inflammatory responses play an important role in sugar uptake and the activation of the immune system.

Supporting a balanced intestinal microbial community is essential for the integrity of the immune system, for the prevention and response to infections (inflammation), and for recovery from illness. The microbes and their metabolites influence physiological function (particularly metabolism), local mucosal homeostasis, inflammation, and interactions between multiple body systems. Therefore, an imbalanced intestinal microbiota may have system-wide effects and contribute to blunted immune reactivity. Gut microbiota alterations due to unhealthy lifestyle factors and dietary triggers may contribute to inflammation, intestinal permeability, immune system dysfunction, and the pathogenesis of a broad spectrum of chronic diseases. Healthy lifestyle factors, including a diversified diet, limited consumption of processed and refined foods, and consumption of adequate dietary fiber, may all promote a healthy microbiome and therefore a healthy immune response!

 

CHRONIC inflammation is BAD
Just like how fire is a cleansing process in forests; this process in nature is beneficial when it occurs periodically. It would be harmful if the forest was constantly burning or if it burned down every year. This is what happens in your body with chronic inflammation…the fire never dies out. The cells of your body cannot repair themselves and new, healthy cells can’t form. Your “forest” can’t rebuild and thrive and function as nature intended.
If the agent causing an inflammation cannot be eliminated, or if there is some interference with the healing process, an acute inflammatory response may progress to the chronic stage. Repeated episodes of acute inflammation also can give rise to chronic inflammation. The physical extent, duration, and effects of chronic inflammation vary with the cause of the injury and the body’s ability to ameliorate the damage.

Some of the most common and disabling human diseases, such as tuberculosis, rheumatoid arthritis, and chronic lung disease, are characterized by this type of inflammation. Chronic inflammation can be brought about by infectious organisms that are able to resist host defenses and persist in tissues for an extended period. These organisms include Mycobacterium tuberculosis (the causative agent of tuberculosis), fungi, protozoa, and metazoal parasites. Other inflammatory agents are materials foreign to the body that cannot be removed by phagocytosis or enzymatic breakdown. These include substances that can be inhaled, such as silica dust, and materials that can gain entry to wounds, such as metal or wood splinters.

 

In autoimmune reactions the stimulus to chronic inflammation is a normal component of the body to which the immune system has become sensitized. Autoimmune reactions give rise to chronic inflammatory diseases such as rheumatoid arthritis.

 

We could keep going, but we think you get the idea, chronic inflammation causes many problems for your body. Functional medicine providers specialize in connecting symptoms + health history to pinpoint the type of inflammatory response and finding the root cause/s of unhealthy inflammation by asking questions such as what is damaging the cells? what microorganisms, physical agents, or chemicals are prevalent? are the intestinal microbial communities balanced?

Now you have a more in-depth understanding of what inflammation is…the body on fire and this fire is your body’s response to damaged cells. Discover what is causing the damage to cells and you can reduce inflammation.

Schedule a Consult with a Provider

 

Resources & Further Reading:

Britannica, The Editors of Encyclopaedia. “Inflammation”. Encyclopedia Britannica, 2 Nov. 2020, https://www.britannica.com/science/inflammation.

Cammarota G, Ianiro G. Gut microbiota and cancer patients: a broad-ranging relationship. Mayo Clin Proc. 2017;92(11):1605-1607. doi:1016/j.mayocp.2017.09.009

https://medlineplus.gov/ency/imagepages/9071.htm

Shanahan F, van Sinderen D, O’Toole PW, Stanton C. Feeding the microbiota: transducer of nutrient signals for the host. Gut. 2017;66(9):1709-1717. doi:1136/gutjnl-2017-313872

Categories
Functional Medicine Health Concerns

A Wholistic Approach to Brain Health – Alzheimer’s & Dementia Breakthroughs

Worldwide, 50 million people are living with Alzheimer’s and other dementias.

This illness affects a third of people over the age of 85 in the U.S.  By 2050, there could be as many as 7 million people age 85 and older with Alzheimer’s disease, accounting for half (51%) of all people 65 and older with Alzheimer’s.

Alzheimer’s disease is a degenerative brain disease and the most common form of dementia. Dementia is not a specific disease. It’s an overall term that describes a group of symptoms.

This Brain Dis-ease can rob people of the ability to think clearly, perform everyday tasks and ultimately, remember their family or who they even are. Because the disease is so devastating, and since previous treatments failed to come up with a cure, we’re always on the lookout for Alzheimer’s natural treatment options and Alzheimer’s news, scouring the medical journals for Alzheimer’s breakthroughs.

It is claimed that “no one survives a diagnosis of dementia,” a disease with “no effective treatment.” As practitioners, we have struggled over the years with patients with cognitive decline, since there has been so little to offer… There is still much that we do not know about the brain, but there are several theories for dementia root causes including  free radical damage, an inability to use glucose properly, vitamin deficiencies or environmental toxins that can be used to improve cognitive function and, perhaps, prevent dementia and its related diseases such as Alzheimer’s.

Understanding the Brain

Your brain is your most powerful organ, yet weighs only about three pounds. It has a texture similar to firm jelly. It is comprised of 3 main parts: the cerebrum, the cerebellum, and the brain stem.

Your brain is nourished by one of your body’s richest networks of blood vessels. When you are thinking hard, your brain may use up to 50 percent of the fuel and oxygen. With each heartbeat, arteries carry about 20 to 25 percent of your blood to your brain, where billions of cells use about 20 percent of the oxygen and fuel your blood carries. The whole vessel network includes veins and capillaries in addition to arteries.

Your brain’s wrinkled surface is a specialized outer layer of the cerebrum called the cortex. Scientists have “mapped” the cortex by identifying areas strongly linked to certain functions. Your brain is divided into right and left halves. The right side is responsible for controlling the left side of your body and the left side is responsible for controlling the right side of your body.

Your brain is a NEURON FOREST. Neurons are information messengers. They use electrical impulses and chemical signals to transmit information between different areas of the brain, and between the brain and the rest of the nervous system. Neurons are the chief type of cell destroyed by Alzheimer’s disease.

Cell Signaling & Signal Coding

The real work of your brain goes on in individual cells. The neurotransmitters travel across the synapse, carrying signals to other cells. Scientists have identified dozens of neurotransmitters. Alzheimer’s disease disrupts both the way electrical charges travel within cells and the activity of neurotransmitters.

100 billion nerve cells. 100 trillion synapses. Dozens of neurotransmitters. This “strength in numbers” provides your brain’s raw material. Over time, our experiences create patterns in signal type and strength. These patterns of activity explain how, at the cellular level, our brains code our thoughts, memories, skills and sense of who we are.

Understanding How Alzheimer’s and Dementia Affects the Brain

Alzheimer’s disease leads to nerve cell death and tissue loss throughout the brain. Over time, the brain shrinks dramatically, affecting nearly all its functions.

Scientists can also see the terrible effects of Alzheimer’s disease when they look at brain tissue under the microscope. Scientists are not absolutely sure what causes cell death and tissue loss in the Alzheimer’s brain, but the plaques and tangles in the figures below are prime suspects.

Alzheimer’s tissue has many fewer nerve cells and synapses than a healthy brain.

More About Plaques…

More About Tangles…

Tangles destroy a vital cell transport system made of proteins. This electron microscope picture shows a cell with some healthy areas and other areas where tangles are forming.

In healthy areas:

  • Orderly, parallel strands for delivering key materials to the cells
  • A protein called tau helps keep the strands straight

In areas where tangles are forming:

Nutrients and other essential supplies can no longer move through the cells, which eventually die.

  • Tau collapses into twisted strands called tangles
  • The strands can no longer stay straight and disintegrate

Progression Through the Brain

Plaques and tangles tend to spread through the cortex in a predictable pattern as Alzheimer’s disease progresses. The rate of progression varies greatly. On average, a person with Alzheimer’s lives four to eight years after diagnosis, but can live as long as 20 years, depending on other factors. The course of the disease depends in part on age at diagnosis and whether a person has other health conditions.

In the earliest stages, before symptoms can be detected with current tests, plaques and tangles begin to form in brain areas involved in.

In mild to moderate stages, brain regions important in memory and thinking and planning develop more plaques and tangles than were present in early stages. As a result, individuals develop problems with memory or thinking serious enough to interfere with work or social life. They may also get confused and have trouble handling money, expressing themselves and organizing their thoughts. Many people with Alzheimer’s are first diagnosed in these stages.

As Alzheimer’s progresses, individuals may experience changes in personality and behavior and have trouble recognizing friends and family members.

In advanced Alzheimer’s disease, most of the cortex is seriously damaged. The brain shrinks dramatically due to widespread cell death. Individuals lose their ability to communicate, to recognize family and loved ones and to care for themselves.

Using Functional Medicine To Treat Alzheimer’s And Cognitive Decline

With functional medicine, the goal is to treat the root cause of the issue instead of only alleviating the resulting symptoms. For instance, the leading hypothesis from conventional medicine asserts that amyloid plaques in the brain cause Alzheimer’s and aims to remove the plaques to cure Alzheimer’s. Thus, billions of dollars have been invested in trials to clear amyloid-beta with no success to date.  In fact, there is some evidence that several have worsened cognitive decline.

Functional medicine goes deeper. Rather than solely focusing on the removal of amyloid plaques, functional medicine asks why plaques arise and seeks to prevent their development in the first place.

The whole-body systems approach of functional medicine has proven optimal for treating the chronic illnesses that lead to Alzheimer’s disease, including obesity, diabetes, hypertension, heart disease, and more. Consequently, these efforts have led to unprecedented success for treating Alzheimer’s.

Alzheimer’s Is a Multifactor Pathological Condition

Dr. Dale Bredesen, a renowned AD researcher, goes against popular opinion and states that AD is a multifactor pathological condition. Amyloid-beta is not the main problem, but rather the brain’s response to one (or more than one) insult (3). By removing the insults and optimizing health, this method has reversed AD in many cases. Through years of work, Dr. Bredesen has identified several types of AD, each with unique causes (45):

  • Type 1 (“inflammatory”) is due to an antimicrobial response to pathogens or other inflammatory causes.
  • Type 2 (“atrophic”) is associated with reductions in factors that support brain health, like estradiol, progesterone, testosterone, insulin, and vitamin D.
  • Type 1.5 (“glycotoxic”) is a composite of types 1 and 2. Inflammation from high blood glucose levels combines with a trophic loss of insulin sensitivity.
  • Type 3 (“toxic” or “cortical”) is associated with exposure to toxins or toxicants (a toxicant is any toxic substance; toxicants can be poisonous and they may be man-made or naturally occurring) such as heavy metals, insecticides/pesticides, antimicrobials, and commercial/industrial toxins.
  • Type 4 (“vascular”) is associated with reduced vascular support.
  • Type 5 (“traumatic”) is associated with previous head trauma.

Your Lifestyle & Environment Play Key Roles

Since lifestyle and environmental factors play a major role in the onset and progression of Alzheimer’s disease, a functional medicine approach is the ideal strategy for addressing Alzheimer’s at its roots. To accomplish this goal the Functional Medicine operating system consists of the Functional Medicine Timeline, Advanced Testing, and the Therapeutic Lifestyle Factors (Sleep & Relaxation, Movement & Exercise, Nutrition, Stress, and Relationships). Advanced Testing allows the practitioner to evaluate imbalances at the cellular level. This helps sort out why the disease has occurred in the first place. By understanding each of these imbalances, the patient is empowered & supported to make changes to correct them!

Schedule a Free Consultation

Ready to talk with a provider about getting to the root of you or your loved ones cognitive decline and discover pathways to healing? Our staff and practitioners are eager to help you!

Further reading & research:

The New Era of Alzheimer’s Treatment with Dale Bredesen, MD

https://www.alz.org/abam/overview.asp#takeActionBox

https://www.alzheimers.net/alzheimers-statistics

https://pubmed.ncbi.nlm.nih.gov/?term=Bredesen+D

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505565/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789584/

https://pubmed.ncbi.nlm.nih.gov/25654508/

Categories
Functional Medicine

What Your Medical Practitioner Should Be Asking You – But Probably Isn’t

Uncovering the “why” behind your symptoms is key to unlocking true healing. The “why” is found within your life story. Our practice was created to give you and your practitioner the time necessary to uncover the intricacies of your health journey.
Your health journey starts the moment your life begins. Here are some questions & reasons your functional medicine provider may ask you when starting to uncover the “why’s” behind physical symptoms.

“In the United States, about half the C-sections we do appear to be avoidable. This study is the first to estimate the potential population-wide harms of this trend to mothers over the long term” – co-author Dr. Neel Shah, who leads the Delivery Decisions Initiative at Ariadne Labs

Did your mother give birth to you vaginally or by C-Section?

A caesarean section (CS) can be a life-saving intervention when medically indicated, but this procedure can also lead to short-term and long-term health effects for women and children. Given the increasing use of CS, particularly without medical indication, an increased understanding of its health effects on women and children has become crucial.

There is emerging evidence that babies born by CS have different hormonal, physical, bacterial, and medical exposures, and that these exposures can subtly alter neonatal physiology. Short-term risks of CS include altered immune development, an increased likelihood of allergy, atopy, and asthma, and reduced intestinal gut microbiome diversity.

The persistence of these risks into later life is less well investigated, although an association between CS use and greater incidence of late childhood obesity and asthma are frequently reported. There are few studies that focus on the effects of CS on cognitive and educational outcomes. The study, published in the Aug 9 issue of JAMA Surgery, was led by researchers at Aalborg University in Denmark and at Ariadne Labs in Boston. More than 23 million women across the globe have C-sections each year, making it the most common surgery in the world by far. More than one million women have hysterectomies later in life to remove their uterus, most often because of pain and/or bleeding.

Understanding potential mechanisms that link CS with childhood outcomes, such as the role of the developing neonatal microbiome, has potential to inform practitioners so they can better aid in restoring patients to optimal health.

What were some of your biggest losses, traumas & life events?

Providers need to understand how trauma can affect treatment presentation, engagement, and the outcome of physical, mental, emotional, and behavioral health services. Trauma, including one-time, multiple, or long-lasting repetitive events, affects everyone differently.

Immediate and Delayed Reactions to Trauma

Some individuals may clearly display criteria associated with posttraumatic stress disorder (PTSD), but many more individuals will exhibit resilient responses or brief subclinical symptoms or consequences that fall outside of diagnostic criteria. The impact of trauma can be subtle, insidious, or outright destructive. How an event affects an individual depends on many factors, including characteristics of the individual, the type and characteristics of the event(s), developmental processes, the meaning of the trauma, and sociocultural factors.

From sleep disorders to food addictions/coping mechanisms, working with a provider to recognize traumas & triggers, create safe environments, and aid in re-regulating nervous systems in healthy & helpful manners can help restore mental, emotional, and physical well-being.

Were you exposed to antibiotics early in life?

During birth, a relatively sterile unborn child becomes a newborn coated with microbes on every surface. This collection of bacteria, archaea, viruses, and fungi found in and on the human body is called the microbiota. The collective genomes of the microbiota are considered to be the metagenome, and the totality of the microbiota, metagenome, and their interactions is the microbiome. The microbiota has many critical functions including protection from pathogens, development and maintenance of the immune system, and helping the host access nutrients in food. The gut microbiota has been of particular interest, as perturbations of this community have been linked to disease states including autoimmune disease and neurological disorders. Antibiotics have consistently been shown to change the gut microbiome in humans and animals.

The infant gut microbiota increases in diversity and richness while becoming more stable over time, especially once solid foods are introduced into the diet, until the community resembles an adult-like state at around three years old.

Since the gut microbiota is important in host immune development, nutrient absorption, and protection from pathogens, changes in the community composition could have deleterious effects on the host. The spectrum of diseases for which an altered gut microbiota has been implicated is quite broad. Several excellent reviews have focused on the relationship between the microbiota and host immunity. One critical aspect of this field is that T cell populations in the gut can be influenced by the microbiota and its metabolites. One of the most studied groups of bacterial metabolites, short-chain fatty acids, have been shown to exert epigenetic regulation of transcription factor genes to influence regulatory T cells in the gut. Changes in T cell populations are one mechanism by which alterations in the gut microbiota may be contributing to autoimmune diseases including inflammatory bowel disease (IBD), asthma, allergies, arthritis, and multiple sclerosis (MS) Thirteen studies, including a total of 527 504 children, were included in a systematic review and concluded exposure to antibiotics in infancy was associated with an increased odds ratio (OR) of childhood overweight and obesity.

Understanding your unique gut microbiome is vital to creating an environment that allows the rest of your body to function properly & thrive!

Were you breastfed as a child?

Health outcomes in developed countries differ substantially for mothers and infants who formula feed compared with those who breastfeed. For infants, not being breastfed is associated with an increased incidence of infectious morbidity, as well as elevated risks of childhood obesity, type 1 and type 2 diabetes, leukemia, and sudden infant death syndrome. For mothers, failure to breastfeed is associated with an increased incidence of premenopausal breast cancer, ovarian cancer, retained gestational weight gain, type 2 diabetes, myocardial infarction, and the metabolic syndrome.

Compared with breastfed infants, formula-fed infants face higher risks of infectious morbidity in the first year of life. These differences in health outcomes can be explained, in part, by specific and innate immune factors present in human milk. Plasma cells in the mother’s bronchial tree and intestine migrate to the mammary epithelium and produce IgA antibodies specific to antigens in the mother-infant dyad’s immediate surroundings, providing specific protection against pathogens in the mother’s environment. In addition, innate immune factors in milk provide protection against infection.

Not breastfeeding or weaning prematurely is associated with health risks for mothers as well as for infants. Epidemiologic data suggest that women who do not breastfeed face higher risk of breast cancer and ovarian cancer, as well as obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease. As in the pediatric literature, most evidence arises from observational studies, which are subject to confounding by other health behaviors. For maternal health outcomes, associations are generally reported according to lifetime duration across all pregnancies, rather than duration of feeding for each pregnancy.

Given the compelling evidence for differences in health outcomes, breastfeeding should be acknowledged as the biologic norm for infant feeding. Physician counseling, clinics, and hospital practices should be aligned to ensure that the breastfeeding mother-infant dyad has the best chance for a long, successful breastfeeding experience. And, if it is not an option for a mother, practitioners should be informed so that they can best support the mother and infant through supplementary practices.

Did you achieve puberty at an early age?

Adolescence is increasingly recognized as a critical period in the life course, a time when rapid development of the brain, body, and behaviors opens a window of opportunity for interventions that may affect health throughout life.

Puberty results in very rapid somatic growth, brain development, sexual maturation, and attainment of reproductive capacity. It is accompanied by final maturation of multiple organ systems and major changes in the central nervous system and in psychosocial behavior ().

 A range of social determinants of health arise in adolescence, with peers, schools, and eventually the workplace becoming strong determinants of health and well-being as the influence of the family wanes (). These social changes are apparent even in traditional or more sociocentric cultures. More than half of the top 10 risk factors identified in the Global Burden of Disease study () are largely determined during adolescence.

Adolescence is also a time when young people may modify or alter the pathways to adult health or illness (). Early life experiences may reinforce both good and poor trajectories. Similarly, resilience during adolescence may improve outcomes for young people born into adversity. The transfer from primary to secondary school, sexual debut, and entry into the labor market may be critical points for preventing the accumulation of health risk ().

Adolescence is a time of great developmental plasticity and risk for the onset of a range of disorders that can carry a high burden of disease throughout the lifespan. It offers a critical developmental window of opportunity for intervention and prevention. Puberty and brain development during adolescence are responsible for dramatic shifts in burden of disease, away from childhood conditions toward injuries and emerging noncommunicable diseases. Knowledge of the unique developmental processes that characterize adolescence and the role they play in both risk and opportunity during this phase of life is expanding rapidly. What remains is the task of translating this knowledge into intervention and prevention methods that target modifiable, developmentally sensitive mechanisms to maximize the effectiveness of intervention approaches during this phase of life.

What is your work environment like?

Chronic, sustained exposure to stressful working conditions can result in a variety of long term health problems, including: Cardiovascular disease, Musculoskeletal disorders, & Psychological disorders.

Objectively assessed job demands were significantly associated with blood pressure and Cortisol levels. The model also predicted elevations in physiological responses after individuals left work, suggesting that potentially health-impairing reactions to jobs that have high demands and low controllability might carry over to home settings and thus pose a high risk of long-term health impairment. The results have implications for the role of personal control in occupational stress.

The goal is to create conditions that do not trigger the biologic and behavioral pathways to disease & disorders. Creating and implementing practices and environmental support requires leadership and strong cross-functional collaboration outside of the traditional structures for workplace health, safety and wellness.

Knowing the impact your environment has on your overall well-being is crucial to learning how to aid your body through nutrients, adaptogens, and healthy stress management practices.

At Kingdom Health & Wellness…

We want to help you make connections between events in your life and the current state of your health. That’s why we often refer to holistic medicine as the “investigative journalism” of medicine.
We believe a practitioner should take the time to go through your health history in depth, perform advanced testing, and help you create a game-plan to address the lifestyle factors necessary to truly make a difference and improve the quality of your life.

Schedule an appointment

 

Resources:
Center for Substance Abuse Treatment (US). Trauma-Informed Care in Behavioral Health Services. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 2014. (Treatment Improvement Protocol (TIP) Series, No. 57.) Chapter 3, Understanding the Impact of Trauma. Available from: https://www.ncbi.nlm.nih.gov/books/NBK207191/

Champagne N, et al. Obesity/Overweight and the Role of Working Conditions: A Qualitative Participatory Investigation. Univ. Mass. Lowell, Oct 2012. www.uml.edu/research/centers/CPH-NEW.

Development of the human gastrointestinal microbiota and insights from high-throughput sequencing.

Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R
Gastroenterology. 2011 May; 140(6):1713-9.
Rasmussen SH, Shrestha S, Bjerregaard LG, Ängquist LH, Baker JL, Jess T, Allin KH. Antibiotic exposure in early life and childhood overweight and obesity: A systematic review and meta-analysis. Diabetes Obes Metab. 2018 Jun;20(6):1508-1514. doi: 10.1111/dom.13230. Epub 2018 Feb 25. PMID: 29359849.
Sandall J, Tribe RM, Avery L, Mola G, Visser GH, Homer CS, Gibbons D, Kelly NM, Kennedy HP, Kidanto H, Taylor P, Temmerman M. Short-term and long-term effects of caesarean section on the health of women and children. Lancet. 2018 Oct 13;392(10155):1349-1357. doi: 10.1016/S0140-6736(18)31930-5. PMID: 30322585.
Stuebe, Alison. “The risks of not breastfeeding for mothers and infants.” Reviews in obstetrics & gynecology vol. 2,4 (2009): 222-31.

Succession of microbial consortia in the developing infant gut microbiome.

Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R, Angenent LT, Ley RE
Proc Natl Acad Sci U S A. 2011 Mar 15; 108 Suppl 1():4578-85.